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Nivel de evidencia La evidencia es limitada: sobre todo in vitro y proveniente de un mismo grupo de investigacin, sin replicacin independiente amplia

, who identified the natural compound rhein as a first-in-class, competitive inhibitor that targets the catalytic site of FTO in biochemical assays[257]

[DOI] [PubMed] [Google Scholar] 120.Wang L., Wang N., Zhang W., Cheng X., Yan Z., Shao G., Wang X., Wang R., Fu C

a large number of issues that cloud the interpretation of a small observed effect. Lumakras was approved under the FDAs accelerated approval pathway in May 2021

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