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Substantial evidence has demonstrated that dysbiosis mediates the reciprocal influence between constipation and depressive symptoms through inflammatory activation, neurotransmitter imbalance, and metabolic dysregulation, forming a vicious cycle

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Most importantly, exosomes have been shown to transport iron out of the cell to regulate ferroptosis ( Publishers Note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

10.1155/2020/2596082 17 ArafaH

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[106] showed that although CKD patients have lower plasma zinc levels than healthy people, erythrocyte zinc levels were higher than those of controls regardless of whether they were on maintenance hemodialysis