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In the area of antihepatic fibrosis, ISL could inhibit Annexin A2 expression and block the sphingosine kinases/sphingosine-1-phosphate/IL-17 signaling pathway (Liu et al., 2023), yet, QE decreased hepatic mRNA levels of SphK1 and NLRP3 (Salama et al., 2024)

Fisch, K

In: Handbook of Vitamins

2021;220(12):e202006049

Although the incidence rate of primary malignant brain tumors is relatively low compared to other tumors (approximately 6.6 per 100000) [382], nevertheless they are touted as the most lethal type of tumors with their general median survival period of less than 2 years