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Nevertheless, the insulin resistance and abdominal adiposity seems to be essential in the pathophysiological process, and for this reason, based on the information available, we propose IGF-1 as a key hormone in the pathophysiology of metabolic syndrome due to its implications in the metabolism of carbohydrates and lipids

Tomida M, Ohtake H, Yokota T, Kobayashi Y, Kurosumi M (2008) Stat3 up-regulates expression of nicotinamide N -methyltransferase in human cancer cells

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5-amino-1MQ and 7-amino-1MQ produced modest cytotoxicity relative to untreated cells (P 0.05, n.s.)