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Biosensing with plasmonic nanosensors

Retention of LDL in the intima, due to interactions with extracellular matrix such as chondroitin sulfate-rich proteoglycans, sequesters LDL away from the antioxidant environment of the plasma and exposes LDL to oxidation

This is a remarkable story because glutathione is one of the most important antioxidants in the body

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Moreover, the rupture of the blood vessel wall in hemorrhagic stroke results in the accumulation of hemoglobin and heme iron at the extracellular milieu and subsequent iron-induced LPO and ferroptosis, thereby furtherly exacerbating the stroke-induced brain injury

particularly for patients in developing countries and from lower-income backgrounds, genetic testing may not be an option