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Discover how DSIP targets sleep architecture, not timing

So the logic that people have waged is that drugs like metformin or compounds like berberine that reduce mTOR levels or impact the mTOR pathway in ways that lead to net decreases in mTOR-- the logic is that that could somehow increase lifespan

Bauman, M.L

Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells

Li R, Cui K, Wang T, Wang S, Li X, Qiu J

Analysis of adverse effects (OR = 0.03, 95% CI: 0.030.09) revealed comparable safety profiles, with reported events primarily consisting of gastrointestinal symptoms (abdominal pain, nausea, reflux, diarrhea, constipation, flatulence, and indigestion), neurological effects (headache and daytime drowsiness), and occasional hypersensitivity reactions or cold sores