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Moreover, in isolated rat cardiac MVECs treated with Ang II (4 nM) during 48 h, an induction of apoptosis was observed via regulation of the protein tyrosine phosphatase 1B/PI3K/Akt pathway [96]

One notable mechanism involves the upregulation and/or activation of receptor tyrosine kinases (RTKs), leading to the phosphorylation of glucose transporters and their subsequent relocation to the plasma membrane (Schafer et al

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6.2 Dose dependent dual roles: from antioxidant to prooxidant Polyphenols exhibit dual effects of antioxidant and prooxidant at different concentrations