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Small batch production and refrigerated storage maintain potency

Boccella S, De Filippis L, Giorgio C, et al

High-dose oral B12 (e.g., 1,000 mcg) is commonly used to correct deficiency because only a small fraction is absorbed

The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole

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This study aimed to evaluate stroke characteristics and outcomes in people with ischemic stroke (pwIS) of different Middle Eastern ethnic backgrounds