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SAC treatment markedly reduced ROS levels, restored GSH levels, and attenuated MDA accumulation, demonstrating its efficacy in alleviating oxidative stress and lipid peroxidation in UC mice

10.1016/j.it.2021.05.004 90 QianY.GuanT.HuangM.CaoL.LiY.ChengH.et al (2012)

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For instance, mechanical disruption of the BBB facilitates the infiltration of blood-borne molecules and contributes to ROS production and proinflammatory mediator release, which further compromise BBB integrity

In a first part, I discuss biological issues related to the persistence of microbial antigens, dysregulated immune responses, reactivation of latent viruses, different potential self-sustained inflammatory loops, mitochondrial dysfunction, metabolic disorders in the tryptophan- kynurenin pathway (TKP) with impact on serotonin, and consequences of a dysfunctional bidirectional microbiota-gut-brain axis

In the internal metabolome, two types of phosphatidylserines (PSs) were identified