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The significance of these findings lies in the comprehensive understanding of Hgs impact on organ, tissue, cellular, and molecular functioning leading to cardiovascular dysfunction

VPA is also known to modulate gene expression via inhibition of histone deacetylase 56 , and in particular, VPA has been shown to reduce expression of NLGN3 57 , thus mimicking the effect of the genetic manipulation in Nlgn3 R451C KI mice and Nlgn3 KO rats

The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males