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Informed consent was obtained from all participants, who were debriefed at the end, and experiments were performed in accordance with the Declaration of Helsinki and approved by the Cantonal Ethics Committee of Vaud, Switzerland

It is very likely, therefore, that HIF-1's oxygen responsiveness resides over a permissive range of antioxidant buffering capacities, with the demonstration that the antioxidant/pro-oxidant equilibrium effectively uncouples HIF-1 activity from the normal pattern observed in response to variations in p O 2 in the alveolar epithelium [13, 14, 82]