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In the lamina propria, some GIP glutamines are deamidated to glutamate by transglutaminase 2 (TG2) (Zhuang and Khosla, 2020) and subsequently bind to antigen-presenting cells (APCs)dendritic cells, macrophages, and B cells (Wei et al, 2020)previously activated by pro-inflammatory cytokines such as interleukin (IL)-15 and type-1 interferons (IFNs)

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

Hepatology 2004

Homozygotes for the non-19/non-19 CA allele with non metastatic BrCa have been found to have favorable prognostic factors and longer disease-free and overall survival [41], while HER2+ patients carrying the rare SNP rs2946834 allele have poorer prognosis and decreased event-free survival probably due to increased IGF-1 circulating levels [42]

Proteostasis, under the regulation of the circadian system (via mTOR, and proteasome activity) (Juste et al., 2021) reciprocally induces the degradation of core circadian proteins like BMAL1, contributing to age-associated circadian disruptions and accelerated aging phenotypes (Lipton et al., 2017