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Third, the K m value (Michaelis constant) of laccase for O 2 (2050 M) 16 is in the range of physiological O 2 concentrations in tissue (2964 M in the human brain for example 17 ), suggesting potential in vivo applicability

247 Second, clinically-important subgroups could be identified a priori and evaluated for treatment responses

In two Phase 2 clinical trials covering stasis and pressure ulcers, TB4 accelerated healing by almost a month in patients who achieved complete wound closure