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Patients who present with more extensive disease are usually treated with single-agent chemotherapy such as chlorambucil or combination chemotherapy

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Cao C, Yang N, Su Y, Zhang Z, Wang C, Song X, et al

In addition to the immuno-inflammatory mechanisms associated with binding to GPRs, SCFAs enter the liver directly through the portal vein and promote triglyceride synthesis (from acetic acid) and gluconeogenesis (from propionic acid), which have been implicated in the development of NAFLD (177)

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Abbreviations ALA: Alpha-lipoic acid (-lipoic acid) APO: Apocynin CAT: Catalase GPx: Glutathione peroxidase GR: Glutathione reductase GSH: Reduced glutathione GSHt: Total glutathione GSSG: Glutathione disulfide HFD: High-fat diet LFD: Low-fat diet OS: Oxidative stress OVA: Ovalbumin P: Probiotic ROS: Reactive oxygen species SFD: Standard fat diet SOD: Superoxide dismutase References Maniscalco M, Paris D, Melck DJ, DAmato M, Zedda A, Sofia M, Stellato C, Motta AJ