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An elevated level of miR-886-3p in FRDA is associated with the downregulation of the FXN gene and the use of anti-miR-886-3p or the HDAC inhibitor 4b alone has been shown to partially reverse FXN gene repression by reducing miR-886-3p levels (Mahishi et al., 2012

CYP2D6 was the primary enzyme mediating eutylone O -demethylenation, with secondary contributions from CYP2C19 and CYP2B6

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doi: 10.3390/jcm10184230

Am J Med 104(3):246-51, 1998

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