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10.1248/yakushi.18-00169-2 Yakugaku Zasshi 189 SazegariS.Akbarzadeh NiakiM.AfsharifarA.NiaziA.DerakhshandehA.Moradi VahdatM.et al

Unfortunately, the neuroprotective potential of these drugs remains unproven in human clinical trials, as most studies to date have not been designed to evaluate disease-modifying effects

Physiological hyperglycemia generates increased levels of ROS from mononuclear cells, which activate the release of tumor necrosis factor- (TNF-) and increase the inflammatory transcription factor nuclear factor-kappa B (NF-B)