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The survey found that 78.8% of patients had an overall positive experience, 12% had adverse effects, and 86% of patients found the nasal spray to be easy to use

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However, resveratrol has been reported to inhibit cell growth and induce apoptosis in normal cells at high doses, with studies showing that mice consuming large doses experienced fatal outcomes within 34 months [75,76,77,78]

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Melasma is one of the more commonly treated concerns, and many report improvement but because melasma is hormone- and UV-driven, results are best combined with sun protection and, where relevant, hormonal evaluation