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This paradigm shifted with the advent of high-throughput sequencing technologies, particularly 16S rRNA gene profiling and shotgun metagenomics, which unveiled a complex ecosystem harboring several hundred to over a thousand microbial species across the nasopharynx to alveoli [89]

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Despite the look of the MR-1000 being similar to a Les Paul, it obviously didn't feel like one and Ace never brought the guitar to the stage anywhere outside of Japan

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