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Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2

When mitochondrial depolarization and proteasome-dependent rupture of the outer membrane occur, PHB2 binds the autophagosome membrane-associated protein LC3 via the LC3 interaction region structural domain (Fig

Additionally, proteolysis targeting chimeras (PROTACs) offer a novel approach to modulate ferroptosis: PROTACs targeting ACSL4 or Nrf2 have been developed to either induce ferroptosis (in renal cell carcinoma) or enhance antioxidant defense (in CKD), respectively, with improved specificity compared to small-molecule inhibitors

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These transmembrane proteins connect the internal cytoskeleton to the extracellular matrix, enabling cells to sense and respond to their environment

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