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GHK Basic Studies on Insulin-Related Genes and Cellular Longevity Research indicates that GHK may modulate insulin and insulin-like gene expression, possibly impacting cellular lifespan

IL-6, a key proinflammatory cytokine, is upregulated in multiple OA-related joint compartments, including synovial tissue, cartilage, and synovial fluid, where it promotes matrix degradation and inflammation (39)

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It can be challenging to discriminate between hemochromatosis arthropathy and degenerative osteoarthritis (also known as type 1 polyarticular osteoarthritis) [64]