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Oxidative modifications of DNA result in base alterations, formation of single- and double-strand breaks, sister chromatid exchanges and translocation in replicating cells, as well as formation of DNA-DNA and DNA-protein cross-linking (50)

Protonate3D: assignment of ionization states and hydrogen coordinates to macromolecular structures

Conversely, loss of the RB1 gene upregulates the expression of GLS and SLC1A5 genes, further promoting cellular uptake and utilization of glutamine [111]