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Immunohistochemical results revealed an increase in the number of Ki67-positive cells in the CaT and CaT-ME groups when compared to that in the control group, reflecting the ability of the CaT and CaT-ME systems to facilitate skin cell proliferation

Autonomic neuropathy, a component of DPN, can lead to abnormalities in HRV and elevate the risk of silent myocardial ischemia, particularly in patients with T2DM