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Symptoms of vitamin B12 deficiency include: fatigue, irritability, anxiety, low energy, depression, forgetfulness, constipation, new food sensitivities, hot and cold flashes, sore muscles, pale skin, numbness, tingling, and dermatitis

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A study conducted at the University of Texas Southwestern Medical Center found that NNMT inhibition in obese mice reduced body weight by 7% over four weeks without changes in food intakea reduction driven entirely by increased energy expenditure

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The compound shows high enzymatic selectivity, preserves lean mass, and engages longevity-related pathways (e.g., SIRT1), but remains a nonFDA-approved research substance that is WADA-banned and should be used under medical guidance