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While fructose and glucose have the same molecular formula (C 6 H 12 O 6 ), they are metabolized by organs quite differently and have divergent effects on hepatic DNL 30

Immunol Lett 225:915 Chen X, Kang R, Kroemer G, Tang D (2021a) Broadening horizons: the role of ferroptosis in cancer

Although most IBPs are LPS-producers, and their purified LPS most likely triggers a M1 phenotype when added to primary MPs, most intact IBPs reprogram the metabolism of MPs differently and beneficially for their replication, e.g., by stimulation of growth hormone receptors, activation of corresponding signaling pathways, activation of oncogenes or inactivation of tumor suppressors by specific IBP effectors

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In humans, the level of GSH varies significantly, as plasma and urine has lower GSH level

Nanotargeting of withaferin efficiently leads to ferroptosis and exerts satisfactory effects on neuroblastoma (22)