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This was achieved by inhibiting autophagy-dependent FT degradation, reducing Fe 2+ levels, and decreasing lipid peroxidation products (MDA and ROS) (Zheng et al., 2021)

Secreted A was increased in D-iNs, and the amount of A was reduced by a high-dose administration of the antioxidant N-acetylcysteine (NAC)

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However, oral treatment with AMX0035 and TUDCA failed to meet primary clinical and electrodiagnostic endpoints in clinical trials

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A study involving aged mice found that spermidine supplementation reduced cardiac hypertrophy and improved left ventricular function