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Further experiments demonstrated that the transfection of these cancer cells with ESM1 mimic upregulated the expression of MMP-2, MMP-3, MMP-9, VEGF, cyclooxygenase-2 and HIF-1 through the PI3K/AKT/mammalian target of rapamycin (mTOR) signaling pathway (53)

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Luo JL, Kamata H, Karin M (2005) IKK/NF-kappaB signaling: balancing life and deatha new approach to cancer therapy