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We also refer to our response to comments in earlier rulemaking (see 88 FR 77184 through 77185) in which we explained that the Shared Savings Program's benchmarking methodology has the potential to mitigate the differences between the 340B-acquired drug payments included in historical benchmark year and performance year expenditure calculations, among other considerations with respect to how the payments amounts would be considered in Shared Savings Program calculations

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14 In order to support the findings presented here, additional MMP transformations in which hydrogen was replaced with a more polar functional group were analyzed

Semaglutide belongs to a class of drugs called GLP-1 receptor agonists, initially developed for diabetes management