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however, its efficacy in treating solid tumors has been limited by the presence of immunosuppressive TME

Domain scores were determined for Rheumatic which included pain and fatigue symptoms (range 0 to 44), Dyspnea (range 0 to 20), Cardiac (range 0 to 16), Headache (migraine and tension scored 0 to 4 each), Ear Sinus (range 0 to 20), Neuro (range 0 to 16), Irritable Bowel Syndrome based on Rome I criteria (range 0 to 32) [88], Bladder (range 0 to 16) and the sum of all items (range 0 to 172)

In a cellular model, UA inhibited neuron-to-neuron transmission of extracellular -syn by modulating dynamin-mediated and clathrin-mediated endocytosis [223](Fig

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The pool of reduced glutathione (GSH) is fueled by glutathione reductase (GR) activity, which catalyzes the reduction of glutathione disulfide (GSSG) to two molecules of GSH by electron transfer from NADPH

Data availability The datasets generated during the current study are available from the corresponding author on reasonable request