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When growth hormone receptors become more abundant on cell surfaces, each molecule of circulating growth hormone produces a stronger effect

In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions.3 10 In rodents, doses as low as 0.5mg/kg were found to be effective in delivering these anti-pain effects.25 In a 70kg human, an equivalent dose would be around 5.6mg, though thats likely higher than necessary: pharmaceutical-grade GHK-Cu normally ranges from 0.5 mg to 2.5mg per injection

For long-term storage, freezing at -20C helps keep it pure and stable

Gwyer et al., 2019

Or they describe it as being done very quickly, with deep injections, overly painful injections, or Botox running down the face

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