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Sigma-Aldrich), aminooxyacetate (500 M, Sigma-Aldrich), dimethyloxalylglycine, N-(methoxyoxoacetyl)-glycine methyl ester (5 mM, Sigma-Aldrich), CPX (1 M, catalog no

The Haybittle-Peto procedure for generating early stopping boundaries will be used (43)

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If a higher amount of solution is needed, the solution is thick, or the solution is known to cause irritation, use another muscle like the ventrogluteal

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