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doi:10.1016/j.mehy.2012.07.034, PMID: 22951418 Marshall HE, Stamler JS (2001) Inhibition of NF-kappa B by S -nitrosylation

Tentatively, the results on light to medium skin tones can be observed within 1-3 months, within 3-6 months on darker skin tones, within 6-12 months on very dark skin tones, and within 18 months and above for even darker skin tones