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data of one representative experiment are shown (A-D, H, I)

Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis

Furthermore, we also noticed a sharp correlation between all miRNAs and fatty acid biosynthesis in these tumors

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Indeed, NRF2-silenced cells showed downregulation of the GSH-synthesising enzymes GCLC and GSR (Supplementary Figure S6B), demonstrating a direct link between NRF2 activity and GSH synthesis