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The identification of alternative targets of HIF hydroxylases is important in order to fully elucidate the pharmacology of hydroxylase inhibitors (PHI)

In primary rat hippocampal neurons, changes to endogenous APP cleavage and the abundance of CTFs were once again observed upon RABGAP1 KD (Appendix Fig

allostatic load pertains to an acute state of persistent perturbation and, ultimately, circumstances of allostatic overload are associated with disease and the body's inability to cope