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It would be interesting to determine if compounds based on the K6 pharmacophore were more potent than the current compounds, as K6 binds with a higher affinity than any published reagent and shows comparable inhibition 5-8,11

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In fact, the association between kidney stones and chronic kidney disease is independent of major kidney disease risk factors like high blood pressure and diabetes: stone formers are at twice the risk for developing decreased kidney function and chronic kidney disease compared with non-formers (Keddis 2013

These conserved mutations are known as mtDNA Haplogroups (mtDNA-HG) and are associated with susceptibility to certain mitochondrial diseases, including Leber hereditary optic neuropathy, as well as non-metabolic diseases such as Parkinsons disease [102,103,104,105,106,107]