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Changes of pulsatile GH secretion profile need to be investigated, probably using the animal models with selected circadian clock gene knock-out

Xu, Q., Yu, Z., Zhang, M., Feng, T., Song, F., Tang, H., Wang, S., & Li, H

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Thus, microbial changes in PD indicate a shift from a symbiotic, neuroprotective microbiota to a pro-inflammatory, neurotoxic microbial composition, which can promote peripheral immune activation, gut barrier failure, and, eventually, neuroinflammation and dopaminergic neuronal death [44]