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the first lab may measure and report a value of 220 pmol/l, and a different lab may measure and report 380 pmol/l, again in the same blood sample (!) There is day-to-day variation of serum B12

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In addition, the SOCS gene is activated by GH signaling and works as a short intracellular negative feedback loop which rapidly down-regulate GHR activity by internalization and receptor ubiquitinoylation resulting in lysosomal and proteasomal degradation (101)