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Two reasons

Seek immediate help for signs of allergic reaction or if you have red flag symptoms, are pregnant, immunosuppressed, or elderly

Inadequate storage Those with liver disorders are at risk, as B12 is mainly stored in the liver

Heating can degrade peptides, so working at room temperature is advisable

These include: Vegetarians and vegans, as vitamin B12 is mainly found in animal products Older adults, as they absorb vitamin B12 less well with age People with gastrointestinal disorders, like celiac disease or Crohns disease, which can block vitamin B12 absorption Those taking certain medications, such as proton pump inhibitors or metformin, which can also block vitamin B12 absorption Its best to talk to a healthcare professional about whether you need vitamin B12 supplements