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While topical estrogen may reverse these changes, the effects of todays low-dose systemic hormone treatments are not well established, raising the need for more concentrated local administration of hormones or newer cosmeceutical agents such as selective estrogen receptor modulators (SERMs), including phytoestrogens that have become major active ingredients for skin care products, especially when addressing estrogen-deficient skin

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Continuous use is needed to maintain results

Clinical efficacy discrepancies: Human clinical trial results for NMN do not always align with those from animal studies

When reduced forms of coenzyme Q 10 (CoQ 10 H 2 ), vitamin C (ascorbate), or glutathione (GSH) reduce oxidized -tocopherol (-TO), they themselves become oxidized (ubisemiquinone, dehydroascorbate, or GSSG)