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For example, ALS presents both sporadic and familial forms, often linked to defective DNA repair, which leads to neuronal damage, premature aging, and subsequent neurodegeneration ( 2.5 Ferroptosis in neurodegenerative pathogenesis Iron is the most abundant transition metal in the human brain and participates in vital CNS functions such as mitochondrial energy transduction, enzymatic catalysis, myelination, synaptic plasticity, and neurotransmitter synthesis and degradation ( Figure 1

In this context, the consideration of dose-dependent side effects, such as exacerbating breathing difficulties in obstructive sleep apnea patients, impaired blood glucose control when consumed with carbohydrate-rich meals, and an increased risk of nighttime falls due to drowsiness, especially in the elderly, is imperative [236,237,238]

The largest increases were recorded in trials for CF, FTD and ALS, with respective rises of 15.7%, 13.1% and 10.8%

Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro

LC3 recruitment is inhibited in the Atg7 knockout mouse model, LAMP2 expression is lower, autolysosome formation is impaired, sperm cytoplasmic clearance and mitochondrial rearrangement are inhibited, and PDLIM1 accumulates owing to impaired clearance, disrupting the assembly of sperm flagella and resulting in blocked sperm formation, reduced sperm motility, and asthenospermia [60, 146]