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Early trials reported it to be generally well tolerated at low doses, but these studies were small and of short duration

San Gabriel Valley Tribune

Nature (2004) 427:3604.10.1038/nature02246 86 GilabertJAParekhAB

Syringaresinol reverses age-related skin atrophy by suppressing FoxO3a-mediated matrix metalloproteinase-2 activation in Copper/Zinc superoxide dismutase-deficient mice

The disease is caused by the abnormal expansion of the GAA repeat sequence in intron 1 of the FXN gene, leading to the reduced expression of the mitochondrial protein frataxin