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A study has shown benefits for combination treatments for dark circles

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The eight items of the Positive and Negative Syndrome Scale capturing the core symptoms critical in defining remission (PANSS-8 [39]) was administered at baseline, 2 weeks, 4 weeks, and at every clinical encounter thereafter on a 24 weekly basis

Furthermore, PD patients with diabetes exhibited higher subscores for postural instability and gait difficulties after controlling for dopaminergic denervation in the SN and striatum ( t = 3.81, P = 0.0005) [32] Apart from motor symptoms, PD is characterized by a wide variety of non-motor features, including dementia, depression, sleep disturbance, orthostatic hypotension, and psychotic symptom [1]