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Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

doi: 10.1016/j.drudis.2012.04.007 176 ZhangYShiLMeiHZhangJZhuYHanXet al

Polyphenols mitigate the necrosis and apoptosis in myocardial cells, decrease the infarct size of heart, and enhance cardiac function by reducing ROS or reactive nitrogen-free radical production stemming from oxidative stress (187) (Figure 4)