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Strippoli GFM, Craig M, Deeks JJ, Schena FP, Craig JC

Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome)

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Proceedings of the National Academy of Sciences, 117 (44), 2708027080

Many years later, a physician named Shinya Yamanaka was pursuing his training in orthopedic surgery when he began to notice how many diseases and conditions exist that physicians actually have no ability to fix or heal (including everything from spinal cord injuries and traumatic brain injuries to orthopedic conditions and autoimmune diseases), and he lost confidence in the surgical approach and instead turned his efforts towards curing diseases from a much more thoughtful scientific approach, which ultimately resulted in one of the greatest discoveries of all time (winning a Nobel Prize in 2012): mature adult cells can in fact be reverted back to a full pluripotent stem cell state, capable of becoming any type of cell or tissue, by just introducing a few simple factors into the cell [104]