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AMPK is thought to be a tumor suppressor, too, essentially starving cells while they attempt to form cancerous tumors (though after cancer has developed, AMPK can sometimes promote tumor growth instead).14 As an antimicrobial agent We know that berberine has long been used as an antimicrobial agent in traditional Chinese medicine, and it remains a treatment for diarrhea from both bacterial infections and noninfectious conditions.16 (Ironically, diarrhea and stomach pain are sometimes side effects when you start taking berberine.)

The copper chaperone ATOX1 is a particularly compelling target in this context