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Extracellular Matrix Remodeling Assays: Utilized in studies focused on matrix structure, cellular adhesion, and signaling between cells and their surrounding environment

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Daily doses of 125 mg/kg for up to 11 days induced vomition, inappetence, depression, difficult locomotion and death while adult dogs receiving 50 mg/kg/day for 14 days had clinical signs of vomition and inappetence