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Chem Biol 2009;16:644-65

But the research is clear that depletion is a consistent factor, and maintaining adequate levels is one of the most important things you can do for long-term brain health

Signs that warrant evaluation include: pain radiating down the arm or leg persistent numbness muscle weakness worsening symptoms over time Imaging and a physical examination help determine the underlying cause of the problem

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The needles are typically quite thin and, therefore, less painful than you might expect