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Animal model SpragueDawley rats (68 weeks, 180230 g) obtained from Guangdong Vital River Laboratory Animal Technology Co., Ltd

The strengths of the Lieber-DeCarli model lie in its cost-effectiveness, straightforward equipment requirements, and ease of operation, leading to reduced mouse mortality rates and substantial cost savings

To make any meaningful adjustments to the treatment plan and to survey findings, standard next steps are essential

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Due to the distinct position of the conjugated N-terminal lipid between Cagri-CTR and Cagri-AMY 1 R, we also determined a structure of CTR-Gs in complex with an analogue of Cagri that lacked the lipid modification (CagriBB) to interrogate the contribution of the acylation to the conformation of Cagri-CTR complex

Furthermore, a two-way ANOVA analysis revealed a nonsignificant change in MDA levels in the midbrain between the duration of IF and the diet regimen intervention ( F = 2.406, p = 0.112)