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Elevated 6PGD and its product Ru5P inhibit AMPK activation by disrupting the active LKB1 complex, which promotes lipogenesis by abolishing AMPK-dependent acetyl-CoA carboxylase 1 (ACC1) phosphorylation and inactivation (90)

Glucose conjugation facilitates GLUT1-mediated transport across the BBB, resulting in increased neuronal uptake and pronounced neuroprotective effects (103)

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doi: 10.1016/j.jid.2018.03.1501 5 RobersonEDOBowcockAM