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For instance, Chaigui granules demonstrated notable antidepressant effects in a CUMS model

doi: 10.1016/j.tibs.2014.02.004 37 WuGMorrisSMJrArginine Metabolism: Nitric Oxide and Beyond

Dose-dependent increase in oxidative stress in Leydig cells leading to cytotoxicity, cell death, and impaired gonadal function

This is also consistent with earlier studies showing that cystine starvation activates GCN2 rather than PERK 47 and the lack of enhanced splicing of the XBP1 mRNA upon erastin treatment 9