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Small (rodent) and large (porcine) animal studies have been conducted that demonstrate the importance of LA as a tight junction regulatory peptide in conditions other than celiac disease, including collagen-induced arthritis in mice and intestinal ischemic injury in pigs

van Wijngaarden E, Davidson PW, Smith T, Evans K, Yost K, Love T, Thurston SW, Watson GE, Zarba G, Burns C, Shamlaye CF, Myers GJ (2013) Autism spectrum disorder phenotypes and prenatal exposure to methylmercury

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Because much of a standard capsule is destroyed by stomach acid, users often take higher and higher doses to see results

TXA is extensively utilized for melasma treatment through various administration routes (systemic, topical, transepidermal, intradermal by intralesional microinjections or microneedling)